NELL-1 in the Treatment of Osteoporotic Bone Loss

NELL-1 in the Treatment of Osteoporotic Bone Loss

NELL-1 is a secreted, osteoinductive protein whose expression rheostatically controls skeletal ossification. Overexpression of NELL-1 results in craniosynostosis in humans and mice, whereas lack of Nell-1 expression is associated with skeletal undermineralization....